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Species-dependent stereoselective drug binding to albumin: A circular dichroism study

✍ Scribed by Marco Pistolozzi; Carlo Bertucci

Book ID: 102079491
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 266 KB
Volume: 20
Category: Article
ISSN: 0899-0042
DOI: 10.1002/chir.20521

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The reversible binding of ethacrynic acid was characterized by a difference circular dichroism method. A 2/1 stoichiometry was determined for the [drug]/[HSA] (human serum albumin) complex. The reversible binding of ethacrynic acid to HSA determines direct competition with ligands that selectivity b