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Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen

✍ Scribed by E. Neirinckx; C. Vervaet; S. De Boever; J.P. Remon; K. Gommeren; S. Daminet; P. De Backer; S. Croubels


Book ID
116874817
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
209 KB
Volume
89
Category
Article
ISSN
0034-5288

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## Abstract The purpose of this study was to compare the hepatic and small intestinal metabolism, and to examine bioavailability and gastro‐intestinal first‐pass effects, of kaempferol in rats. Liver and small intestinal microsomes fortified with either NADPH or UDPGA were incubated with varying co