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Species and strain comparisons of immunosuppression by 2-methoxyethanol and 2-methoxyacetic acid

โœ Scribed by R.J. Smialowicz; M.M. Riddle; W.C. Williams

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
620 KB
Volume
16
Category
Article
ISSN
0192-0561

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Attenuation of 2-methoxyethanol and methoxyacetic acid-induced digit malformations in mice by simple physiological compounds: Implications for the role of further metabolism of methoxyacetic acid in developmental toxicity
โœ Welsch, F. ;Sleet, R. B. ;Greene, J. A. ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 884 KB

The ethylene glycol ether 2-methoxyethanol (ME) and its oxidation product methoxyacetic acid (MAA) are selective embryotoxins and equipotent as inducers of digit malformations when given by gavage to pregnant Cr1:CD-1 ICR BR mice on gestation day 11. Earlier observations showed that the teratogenic