Spatial and temporal control of expression of therapeutic genes using heat shock protein promoters
β Scribed by Claire Rome; Franck Couillaud; Chrit T.W. Moonen
- Book ID
- 116986519
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 563 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1046-2023
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Background: Among the techniques used to induce and control gene expression, a non-invasive, physical approach based on local heat in combination with a heat-sensitive promoter represents a promising alternative but requires accurate temperature control in vivo. mri-guided focused ultrasound (mr
## Abstract The promoter of the human multidrug resistance gene (__mdr1__) harbors stressβresponsive elements, which can be induced __e.g.__, by heat or cytostatic drugs. In previous studies the drugβresponsiveness of the mdr1 promoter was successfully used for the drugβinducible expression of the