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Spastic paraparesis and HTLV-I infection in peru

✍ Scribed by Dr. Richard T. Johnson; Diane E. Griffin; Alberto Arregui; Carlos Mora; Clarence J. Gibbs Jr.; Juan M. Cuba; Luis Trelles; Abraham Vaisberg

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 512 KB
Volume: 23
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.410230734

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✦ Synopsis

Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T-lymphotropic virus type I (HTLV-I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for Thelper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV-I-associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin-2 receptors, and decreased natural killer cell activity.

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