Spasmolytic action of the essential oil from Hyssopus officinalis L. var. decumbens and its major components

✍ Scribed by G. Mazzanti; M. Lu; G. Salvatore

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 99 KB
• Volume: 12
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(1998)12:1+<s92::aid-ptr261>3.0.co;2-9

✦ Synopsis

The spasmolytic activity of the essential oil from Hyssopus officinalis L. var. decumbens (HOD) and its major pure components, linalool, 1,8-cineole and limonene was studied on isolated guinea-pig ileum contracted by acetylcholine and BaCl 2 . HOD and linalool inhibited the acetylcholine-and BaCl 2 -induced contractions in a concentration-dependent manner (IC 50 values: HOD, 37 mg/mL and 60 mg/mL; linalool 10 mg/mL and 51 mg/mL). The antagonism appeared non-competitive. In contrast, 1,8-cineole and limonene showed only a weak spasmogen action.