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Sp1 and Sp3 transactivate the RET proto-oncogene promoter

✍ Scribed by Scott D. Andrew; Patric J.D. Delhanty; Lois M. Mulligan; Bruce G. Robinson

Book ID
117519974
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
473 KB
Volume
256
Category
Article
ISSN
0378-1119

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Missense germline mutations of the RET proto-oncogene have recently been identified in the hereditary cancer syndromes MENZA, MEN2B, and FMTC, all characterized by medullary carcinoma, hut also including phaeochromocytoma in MEN2A and MEN2B and parathyroid disease in MENZA. In addition, somatic RET