Soy, isoflavones, and prostate cancer
โ Scribed by Le Jian
- Book ID
- 102510922
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 449 KB
- Volume
- 53
- Category
- Article
- ISSN
- 1613-4125
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โฆ Synopsis
Abstract
Prostate cancer has marked geographic variations between countries. Genetic, epigenetic, and environmental factors coโcontribute to the development of the cancer. The association between dietary factors and prostate cancer has been investigated and one explanation for the low incidence of the cancer in Asia might be high consumption of fresh vegetables including soybean and its products. Soybean is a species of legume contain high amount of isoflavones including genistein, daidzein, glycitein, and equol, which have a prophylactic effect on prostate cancer. In this article, epidemiological and laboratory studies on the relationship between soybeans, isoflavones and prostate cancer are reviewed and large scale multiethnic epidemiological studies are recommended.
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## Abstract We previously reported that genistein, the bioactive isoflavone of soybeans, acts as a radiosensitizer for prostate cancer. Pretreatment of tumor cells with genistein potentiated radiationโinduced killing __in vitro__ and in orthotopic models __in vivo__. However, pure genistein promote
## Abstract Soy and its constituent isoflavone genistein inhibit the development and progression of prostate cancer (PCa). Our study in both cultured cells and PCa patients reveals a novel pathway for the actions of genistein, namely the inhibition of the synthesis and biological actions of prostag