Although the androgen receptor (AR) has been detected by ligand-binding assays, there is little known about the expression and regulation of the AR gene in human breast-cancer cells. AR mRNA, measured by Northern analysis in 18 cell lines, was found to be expressed predominantly in oestrogen-and pro
SOX9 mediates the retinoic acid-induced HES-1 gene expression in human breast cancer cells
✍ Scribed by Patrick Müller; Justin D. Crofts; Ben S. Newman; Laura C. Bridgewater; Chin-Yo Lin; Jan-Åke Gustafsson; Anders Ström
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 365 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0167-6806
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## Abstract Retinoic acid (RA) and its derivatives inhibit the proliferation of normal human mammary epithelial cells (HMEC) and some breast carcinoma lines by mechanisms which are not fully understood. To identify genes that mediate RA‐induced cell growth arrest, an HMEC cDNA library was synthesiz
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