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Sorafenib monotherapy gives sustainable suppression of FLT3 clone in untreated patients with FLT3-internal tandem duplication positive acute myeloid Leukaemia

✍ Scribed by Babu P. Mohan; Gee-fung How; Yvonne Loh; Yeh-ching Linn

Book ID
114714576
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
60 KB
Volume
157
Category
Article
ISSN
0007-1048

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## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte