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Sonographically guided core biopsy in the assessment of thyroid nodules

✍ Scribed by John N. Harvey; David Parker; Parijat De; Raj K. Shrimali; Mark Otter

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
111 KB
Volume
33
Category
Article
ISSN
0091-2751

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✦ Synopsis

Purpose. This study was conducted to assess the value of sonographically guided core biopsy in the evaluation of thyroid nodules by comparison with fine-needle aspiration cytology (FNAC) performed with and without sonographic guidance.

Methods. We performed a retrospective analysis of a consecutive series of 645 thyroid samples obtained at a single center. Samples came from 422 patients who underwent FNAC (with or without sonographic guidance), sonographically guided core biopsy, or excision of thyroid tissue with or without prior frozen sectioning. Final diagnoses were obtained from surgery or clinical follow-up. Initial and final diagnoses were compared.

Results. Adequate samples for assessment were obtained in 87% of core biopsies, compared with 60% of cytology aspirates (p < 0.001). Sonographically guided core biopsy and sonographically guided FNAC both had zero false-negative rates for the diagnosis of malignancy, compared with a 7.0% falsenegative rate (95% confidence interval, 2.0-12.0%) for aspiration cytology when sonography was not used. With core biopsy, 11% of patients required surgical confirmation of the diagnosis, compared with 43% of patients following FNAC (p < 0.001). There were no major complications following core biopsy.

Conclusions. Sonographically guided core biopsy provides an accurate and safe alternative to FNAC in the assessment of thyroid nodules.

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