Sonographic diagnosis of unifocal langerhans cell histiocytosis of the skull
β Scribed by Allison Holley
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 159 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0091-2751
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
The sonographic (US) findings of unifocal Langerhans cell histiocytosis of the occiput are described. The patient was a 3 yearβold girl who presented with a painful soft tissue mass on the scalp. US demonstrated a large soft tissue mass with destruction of the underlying bone. The mass extended through the bony defect and consisted of a solid intracranial component and a predominantly cystic extracranial component. US is not usually associated with the diagnosis of Langerhans cell histiocytosis but in this case it provided valuable information that led to the primary differential diagnosis of Langerhans cell histiocytosis, which was confirmed by bone biopsy at surgery. Β© 2010 Wiley Periodicals, Inc. J Clin Ultrasound 38:440β442, 2010
π SIMILAR VOLUMES
Langerhans' cell histiocytosis (LCH) is characterized by an accumulation and/or proliferation of cells with a Langerhans' cell (LC) phenotype. The aetiology and pathogenesis of LCH are unknown; it is suggested that LCH is caused by an immunological dysregulation. Production of cytokines is a central
## Abstract Twentyβtwo patients with Langerhans cell histiocytosis (LCH) were managed in the UCLA Department of Radiation Oncology from 1974 to 1987. Their median age was 17 years (range 1β42 years) and median followup 4.5 years (range 1β13 years). Fourteen patients had disease localized to a bone
Six children received etoposide as the single agent for treatment of Langerhans cell histiocytosis (LCH; histiocytosis X). Five were less than 2 years old at diagnosis. All had multiorgan involvement; one had liver and pulmonary dysfunction. Two infants also had clinical signs of immune deficiency.
Sixty-four patients with biopsy-proven Langerhans' cell histiocytosis (LCH, formerly designated as histiocytosis X) were managed at the Children's Hospital of Philadelphia from 1970 through 1984. Their median age was 3 yr (range, 0.1-22 yr). Thirty-three patients had localized lesions affecting a bo