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Some reactions with ω-bromoacetophenone: Synthesis of new Pyrazole, Pyrrole and Furan Derivatives

✍ Scribed by Dr. Fathy M. Abdelrazek

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
347 KB
Volume
332
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

Phenacyl bromide 1 reacts with ethyl cyanoacetate 2 in presence of piperidine catalyst to afford the hexa‐2,4‐diene derivative 5. Ethyl phenacylcyanoacetate 3 was obtained by reaction of 1 with the sodium salt 6. Compound 3 reacts with hydrazines and trichloroacetonitrile to afford the pyrazoles 7a, b and the pyrroles 8 and 9, respectively. The reflux of 3 in acetic/sulphuric acid mixture afforded the furan derivatives 10 and 11.

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