Reactions of 3-aminopyrazole derivatives with cyanothioacetamide and its derivatives: Synthesis and reactions of several new pyrazole and pyrazole[3,2-b]pyrimidine derivatives
✍ Scribed by Fawzy A. Attaby; Sanaa M. Eldin
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 512 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0253-6269
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## Abstract Phenacyl bromide 1 reacts with ethyl cyanoacetate 2 in presence of piperidine catalyst to afford the hexa‐2,4‐diene derivative 5. Ethyl phenacylcyanoacetate 3 was obtained by reaction of 1 with the sodium salt 6. Compound 3 reacts with hydrazines and trichloroacetonitrile to afford the
## Abstract 6‐Aminopyridine‐2(1H)‐thiones **1a,b** reacted with dimethylformamide‐dimethylacetal (DMF‐DMA) to give the corresponding 6‐{[(N,N‐dimethylamino)methylene]amino}pyridine derivatives **2a,b**. The latter compounds reacted with hydrazine hydrate to afford the 3,6‐diamino‐1H‐pyrazolo[3,4‐b]