The present work examines the effects of hexane, ethyl acetate and methanol extracts of Psidium guajava leaves (20,100,500 and 1250 mg/kg) on the central nervous system in mice. The three extracts exhibited mostly dose-dependent antinociceptive effects in chemical and thermal tests of analgesia. The
Some pharmacological effects of the ethanol extract of leaves of Annona diversifolia on the central nervous system in mice
✍ Scribed by M. E. González-Trujano; A. Navarrete; B. Reyes; E. Hong
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 90 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
In the present study we investigated some neuropharmacological effects of the ethanol extract of the leaves of Annona diversifolia (Annonaceae). Intraperitoneal administration of the extract delayed the onset of clonic seizures induced by pentylenetetrazole and delayed the time in the 'rota-rod' and 'swimming' test. In addition, the extract augmented the duration of sleeping time induced by sodium pentobarbital. These results indicate that the ethanol extract of the leaves of A. diversifolia has depressant activity on the central nervous system.
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