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Some optimal control problems in cancer chemotherapy with a toxicity limit

✍ Scribed by J.M. Murray


Book ID
116029506
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
794 KB
Volume
100
Category
Article
ISSN
0025-5564

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Singularity of optimal control in some p
✍ A. Swierniak; Z. Duda πŸ“‚ Article πŸ“… 1994 πŸ› Elsevier Science 🌐 English βš– 465 KB

In the paper, it has been proved that some optimal control problems resulting from the simplest models of cancer chemotherapy lead to singular control solutions. The singularity seems to be a characteristic feature of bilinear models even if dynamics of the drug activity or reaction of critical norm