Some observations on the chemical and stereochemical specificity of the de-alkylation of organophosphorus esters by a hepatic glutathione transferase

A chemical model for the enzymatic mono

A chemical model for the enzymatic mono de-alkylation of (methyl and ethyl) parathion by glutathione-S-transferase

✍ Marie Dolores Maturano; Véronique Bongibault; Michèle Willson; Alain Klaébé; Did 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 341 KB

The NMR study of the reaction of methylparathion with thiol (glutathione) and a tertiary amine shows nnambiguously a sequential transfer of the methyl group firstly to the amine and secondly to the thiol. The reaction stops after a single demethylation. This observation may account for regiospecific