✦ LIBER ✦
A chemical model for the enzymatic mono de-alkylation of (methyl and ethyl) parathion by glutathione-S-transferase
✍ Scribed by Marie Dolores Maturano; Véronique Bongibault; Michèle Willson; Alain Klaébé; Didier Fournier
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 341 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
The NMR study of the reaction of methylparathion with thiol (glutathione) and a tertiary amine shows nnambiguously a sequential transfer of the methyl group firstly to the amine and secondly to the thiol. The reaction stops after a single demethylation. This observation may account for regiospecificity of some glutathione-S-transferases.