Some New Derivatives of Gentisic Acid*

✍ Scribed by Moore, W.E. ;Bope, F.W. ;Christensens, B.V.

• Publisher: Elsevier
• Year: 1954
• Weight: 328 KB
• Volume: 43
• Category: Article
• ISSN: 0095-9553
• DOI: 10.1002/jps.3030430605

✦ Synopsis

Seven new esters of gentisic acid were subjected t o four selected pharmacological testing procedures: acute toxicity, antispasmodic activity, local anesthetic activity, and anticonvulsant activity. All of the seven new esters were more toxic than the parent, gentisic acid, when given intraperitoneally in mice in a soluble form. Of the four esters with amino alcohols, only 2-diethylaminoethyl-5-ethoxy salicylate hydrochloride possessed antispasmodic or local anesthetic activity. None of the four esters of gentisic acid tested for anticonvulsant activity possessed this activity.