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A Physicochemical Study of Gentisic Acid

✍ Scribed by Osol, Arthur ;Kleckner, Lewis J.

Publisher: Elsevier
Year: 1952
Weight: 389 KB
Volume: 41
Category: Article
ISSN: 0095-9553
DOI: 10.1002/jps.3030410609

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📜 SIMILAR VOLUMES

Some New Derivatives of Gentisic Acid*

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Seven new esters of gentisic acid were subjected t o four selected pharmacological testing procedures: acute toxicity, antispasmodic activity, local anesthetic activity, and anticonvulsant activity. All of the seven new esters were more toxic than the parent, gentisic acid, when given intraperitonea

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## Conclusions 1. The Hardy-Wolff-Goodell .pain threshold apparatus can be used to test the release of anesthetics from ointment bases. 2. The tail of the albino rat is a convenient testing organ for ointments. There is a measurable difference in the efficiency of release of anesthetics from dif