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Some neurochemical and neuropharmacological studies on the interactions between mescaline and 1-methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC)

✍ Scribed by B. E. Leonard; P. D. Stonier


Publisher
Springer
Year
1972
Tongue
English
Weight
727 KB
Volume
25
Category
Article
ISSN
0033-3158

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✦ Synopsis


The effect of TtIPC was studied on some pharmacological and neurochemical changes induced in the rat by mescaline. The results show that THPC antagonizes the effect of mescaline on the calorigenic action of cr methyl-m-tyrosine in reserpinized mice. THPC potentiated the depletion of brain dopamine caused by H77/77 in combination with mescaline. In none of the other pharmacological or neurochemical tests was there any evidence that THPC antagonized or potentiated the effects of mescaline.


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