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Some effects of disopyramide and its N-dealkylated metabolite on isolated nerve and cardiac muscle

✍ Scribed by Alison M. Grant; R.J. Marshall; S.I. Ankier


Book ID
118322913
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
455 KB
Volume
49
Category
Article
ISSN
0014-2999

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During steady-state treatment with disopyramide, its main and active metabolite, mono-N-dealkylated disopyramide, was reported to reach concentrations that were equal to or higher than the parent drug in 25% of 70 evaluated patients. This metabolite has been found to have a more pronounced anticholi