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Interactions with the cardiac cholinergic system: Effects of disopyramide and its mono-n-dealkylated metabolite

✍ Scribed by M. Boucher; C. Chassaing; A. Herbet; P. Duchêne-Marullaz


Book ID
118345340
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
479 KB
Volume
50
Category
Article
ISSN
0024-3205

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✍ Lennart Bergfeldt; Karin Schenck-Gustafsson; Rune Dahlqvist 📂 Article 📅 1992 🏛 Springer US 🌐 English ⚖ 860 KB

During steady-state treatment with disopyramide, its main and active metabolite, mono-N-dealkylated disopyramide, was reported to reach concentrations that were equal to or higher than the parent drug in 25% of 70 evaluated patients. This metabolite has been found to have a more pronounced anticholi