✦ LIBER ✦

Some applications of capillary gas chromatography in clinical chemistry

✍ Scribed by Liebich, H. M. ;Wahl, G.

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 374 KB
Volume: 12
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240120907

No coin nor oath required. For personal study only.

✦ Synopsis

Profile analysis using capillary gas chromatography is applied in clinical chemistry to detect metabolic abnormalities. Examples are the increase of the urinary excretion of aromatic acids carrying a 4-hydroxyl group and the decrease of hippuric acid in liver cirrhosis, and the elevated concentrations and excretions of dicarboxylic, oxocarboxylic, and hydroxycarboxylic acids in diabetes mellitus. Gas chromatographic quantitations, in some instances using mass selective detection, are performed on clinically relevant constituents. An example is the investigation of plasma and urinary hippuric acid and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in different stages of renal diseases.

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