## Abstract **BACKGROUND:** Room temperature ionic liquids (ILs) are attractive alternatives to environmentally unfriendly volatile organic solvents. Partitioning is one of the most important and fundamental properties of a chemical, and the octanol/water partition coefficient is widely used to mea
Some advantages of calculating octanol—water partition coefficients
✍ Scribed by Albert J. Leo
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 286 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0022-3549
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📜 SIMILAR VOLUMES
## Abstract In this work, the possibility of the a priori predictive model COSMO‐RS to describe partitioning of pharmaceutically active compounds in the octanol‐water system (__P__~OW~) in the presence of electrolytes is investigated. It is shown that the calculated values of __P__~OW~ depend on th
Water (2.3 M ) dissolved in octanol( 6) reduces solute solubility in octanol, while octanol(4.5 X lO-3M) in water (9) enhances solute solubility in water. To support this point, the solubilities of these three compounds in water-saturated octanol are shown to be reduced by -10-30% because of water s