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Somatic PTPN11 mutation with a heterogeneous clonal origin in children with juvenile myelomonocytic leukemia

✍ Scribed by Shimada, H; Mori, T; Shimasaki, N; Shimizu, K; Takahashi, T; Kosaki, K


Book ID
110055900
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
87 KB
Volume
18
Category
Article
ISSN
0887-6924

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Background. The use of chemotherapy in juvenile chronic myelomonocytic leukemia (J-CMML) has not generally been successful. Our previous experience in 11 patients demonstrated that chemotherapy with low doses of daunorubicin or cytarabine resulted in a 90% fatal outcome and a median survival rate of