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RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)

✍ Scribed by Flotho, C; Valcamonica, S; Mach-Pascual, S; Schmahl, G; Corral, L; Ritterbach, J; Hasle, H; Aricò, M; Biondi, A; Niemeyer, CM

Book ID: 110054044
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 104 KB
Volume: 13
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2401240

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Background. The use of chemotherapy in juvenile chronic myelomonocytic leukemia (J-CMML) has not generally been successful. Our previous experience in 11 patients demonstrated that chemotherapy with low doses of daunorubicin or cytarabine resulted in a 90% fatal outcome and a median survival rate of