The human homologue (PTCH) of the Drosophila segment polarity gene patched has recently been identified as a tumorsuppressor gene for nevoid basal cell carcinoma syndrome and for sporadic basal cell carcinomas of the skin. We analyzed 30 esophageal squamous cell carcinomas (ESCC) for intrageneic mut
Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours
✍ Scribed by Nister, M; Collins, V P; Toftgård, R; Vorechovský, I; Tingby, O; Hartman, M; Strömberg, B
- Book ID
- 110060929
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 466 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
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Mutations in the human homologue of Drosophila patched (PTCH) have been identified in patients with nevoid basal cell carcinoma syndrome (NBCCS; also called Gorlin syndrome) as well as sporadic basal cell carcinomas and medulloblastomas. However, using PCR-SSCP analysis, mutations in PTCH have been
Primitive neuroectodermal tumors (PNETs) represent the most frequent malignant brain tumors in childhood. The majority of these neoplasms occur in the cerebellum and are classified as medulloblastomas (MB). Most PNETs develop sporadically; however, their incidence is highly elevated in patients carr