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Overexpression of the human homologue of Drosophila patched (PTCH) in skin tumours: specificity for basal cell carcinoma

✍ Scribed by NAGANO; BITO; KALLASSY; NAKAZAWA; ICHIHASHI; UEDA


Book ID
104458972
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
278 KB
Volume
140
Category
Article
ISSN
0007-0963

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The human homologue of Drosophila patched (PTCH), located at chromosome 9q22.3, was recently identified as a candidate tumor suppressor gene for familial and sporadic basal cell carcinomas. Squamous cell carcinomas (SCCs) of the skin display allelic loss in this chromosomal region, which, in additio