Mutations in the human homologue of Drosophila patched (PTCH) have been identified in patients with nevoid basal cell carcinoma syndrome (NBCCS; also called Gorlin syndrome) as well as sporadic basal cell carcinomas and medulloblastomas. However, using PCR-SSCP analysis, mutations in PTCH have been
Overexpression of the human homologue of Drosophila patched (PTCH) in skin tumours: specificity for basal cell carcinoma
β Scribed by NAGANO; BITO; KALLASSY; NAKAZAWA; ICHIHASHI; UEDA
- Book ID
- 104458972
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 278 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0007-0963
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The human homologue (PTCH) of the Drosophila segment polarity gene patched has recently been identified as a tumorsuppressor gene for nevoid basal cell carcinoma syndrome and for sporadic basal cell carcinomas of the skin. We analyzed 30 esophageal squamous cell carcinomas (ESCC) for intrageneic mut
The human homologue of Drosophila patched (PTCH), located at chromosome 9q22.3, was recently identified as a candidate tumor suppressor gene for familial and sporadic basal cell carcinomas. Squamous cell carcinomas (SCCs) of the skin display allelic loss in this chromosomal region, which, in additio