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Somatic mitochondrial DNA mutations in human chromophobe renal cell carcinomas

✍ Scribed by Anetta Nagy; Monica Wilhelm; Farkas Sükösd; Börje Ljungberg; Gyula Kovacs

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
147 KB
Volume
35
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

We sequenced the entire mitochondrial genome in 8 chromophobe renal cell carcinomas (RCCs) and corresponding normal kidneys. Our study disclosed 68 known and 45 new sequence variations occurring 132 and 45 times, respectively. We found 6 somatic nucleotide changes in 5 out of the 8 chromophobe RCCs. One A → T substitution occurred in the D‐loop region and an insertion of a 9‐bp sequence in the noncoding region of the MTNC7. One G → A substitution and one C → T substitution were seen in the MTRNR1 and MTRNR2 genes, respectively. One C deletion in MTND5 and one T insertion in the MTND3 gene resulted in frameshift mutations in two tumors. All somatic alterations, with the exception of the 9‐bp insertion, were heteroplasmic changes. Although somatic mtDNA mutations are found in chromophobe RCCs, their role in the maintenance of tumor cell phenotype or in tumorigenesis remains to be elucidated. © 2002 Wiley‐Liss, Inc.

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