Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands

Somatic hypermutation of VκJκ rearrangem

Somatic hypermutation of VκJκ rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs

✍ Sandra J. Foster; Thomas Dörner; Peter E. Lipsky 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB

Productive and nonproductive V O J O gene rearrangements from individual peripheral blood B cells were analyzed for the pattern and distribution of mutations. The eight RGYW motifs and their inverse repeats, WRCY, were present in germ-line V O genes significantly more often than anticipated by rando