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Somatic hypermutation of an immunoglobulin transgene in K transgenic mice

✍ Scribed by O'Brien, R. L.; Brinster, R. L.; Storb, U.

Book ID
109748877
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
611 KB
Volume
326
Category
Article
ISSN
0028-0836

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Hypermutation introduces point mutations into the gene segments encoding immunoglobulin variable regions at a rate that is a million-fold higher than the spontaneous mutation rate in most of the genome. Because Ig enhancers are required to target hypermutation, transcription appears to play a critic