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Analysis of Hypermutation in a Mixed T-Cell Receptor β/Immunoglobulin Heavy Chain Passenger Transgene

✍ Scribed by J. M. JOHNSTON; S. R. IHYER; K-F. TAI; R. S. SMITH; N. L. NADON; W. L. CARROLL


Book ID
119872566
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
386 KB
Volume
764
Category
Article
ISSN
0890-6564

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Analysis of hypermutation in immunoglobu
✍ J. Martin Johnston; Sudhakar R. Ihyer; Robin S. Smith; Kuei-Fang Tai; Tara Farme 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 484 KB

## Abstract Somatic hypermutation of immunoglobulin (Ig) genes plays a critical role in the maturation of the human antibody response. The molecular basis of this important process is, however, unknown. To identify __cis__‐acting sequences that initiate and target hypermutation, we have made three