Analysis of hypermutation in immunoglobu
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J. Martin Johnston; Sudhakar R. Ihyer; Robin S. Smith; Kuei-Fang Tai; Tara Farme
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Article
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1996
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John Wiley and Sons
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English
⚖ 484 KB
## Abstract Somatic hypermutation of immunoglobulin (Ig) genes plays a critical role in the maturation of the human antibody response. The molecular basis of this important process is, however, unknown. To identify __cis__‐acting sequences that initiate and target hypermutation, we have made three