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Somatic gene mutations in vivo as indicated by the 6-thioguanine-resistant T-lymphocytes in human blood

โœ Scribed by Richard J. Albertini


Book ID
113192878
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
903 KB
Volume
150
Category
Article
ISSN
0027-5107

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Deletion and insertion in vivo somatic m
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Deletion and insertion mutations have been found to be a major component of the in vivo somatic mutation spectrum in the hypoxanthine phosphoribosyltransferase (hprt) gene of T-lymphocytes. In a population of 172 healthy people (average age, 34; mutant frequency, 10.3 x 10(-6)), deletion/insertion m