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Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene

โœ Scribed by Beverly A Smith; Mugimane G Manjanatha; Igor P Pogribny; Roberta A Mittelstaedt; Tao Chen; Nancy F Fullerton; Frederick A Beland; Robert H Heflich

Book ID
114071308
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
110 KB
Volume
379
Category
Article
ISSN
0027-5107

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The frequency of point mutations in p53 (exons 4 -7) and in Ki-ras, Ha-ras, and N-ras (exons 1 and 2) and the expression of p53 protein were evaluated in the liver tumors of Wistar rats of a 104week carcinogenicity study on 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a chlorine disinf