✍ Scribed by Rajender S. Varma
No coin nor oath required. For personal study only.
Microwave‐enhanced solvent‐free synthetic approach is described that features simplicity, manipulative ease of the operation and conservation of solvents as the main advantages. This eco‐friendly approach, which has found application in facile organic functional group transformations, is applied to rapid assembly of heterocyclic compounds. A variety of solid state reactions are described that occur rapidly at ambient pressure under solventless conditions and provide ready access to intermediates such as enamines and α‐tosyloxyketones which can be transformed in situ to biologically significant heterocyclic compounds such as isoflav‐3‐enes, flavones, quinolones, 2‐aroylbenzo[b]furans and thiazoles in one‐pot operation. Multicomponent reactions under these solvent‐free conditions can be adapted for high speed parallel synthesis and are exemplified by assembly of dihydropyrimidine‐2(1__H__)‐ones (Biginelli reaction) and imidazo[1,2‐a]annulated pyridines, pyrazines and pyrimidines (Ugi reaction) which may have potential in building a library of such compounds.
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A solvent-free reductive amination of carbonyl compounds by wet montmorillonite K 10 clay supported sodium borohydride is described; microwave irradiation facilitates the procedure.
N-Sulfonylimines are prepared expeditiously in a one-pot solventless operation by microwave thermolysis of aldehydes and sulfonamides in the presence of benign reagents, calcium carbonate and montmofillonite K l0 clay.