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Solvent-free microwave synthesis of bis-pyrazolo[3,4-b:4′,3′-e]-pyridines and study of their antifungal properties

✍ Scribed by J. Quiroga; J. Portilla; B. Insuasty; R. Abonía; M. Nogueras; M. Sortino; S. Zacchino

Publisher: Journal of Heterocyclic Chemistry
Year: 2005
Tongue: English
Weight: 64 KB
Volume: 42
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570420108

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✦ Synopsis

The synthesis of a series of bis-pyrazolo [3,4-b:4',3'-e]pyridines (3) in the reaction of 5-amino-3-methyl-1phenylpyrazole (1) with aldehydes (2) under microwave irradiation and solvent-free conditions is described. The structure elucidation of the products is based on detailed nmr analysis of experiments such as 1 H-COSY, NOESY, DEPT, HSQC and HMBC. These compounds showed moderate antifungal in vitro activity against dermatophytes.

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