Solvent-free microwave multicomponent regiospecific synthesis of pyrimido[4,5-c]isoquinolines and evaluation In Vitro of their antifungal properties

✍ Scribed by Jairo Quiroga; Carlos Cisneros; Braulio Insuasty; Rodrigo Abonía; Manuel Nogueras; Maximiliano Sortino; Susana Zacchino

• Book ID: 102345882
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2006
• Tongue: English
• Weight: 112 KB
• Volume: 43
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570430231

✦ Synopsis

The free-solvent multicomponent reaction under microwave irradiation of 6-aminopyrimidin-4(3H)-ones (1) with dimedone (2) and N,N-dimethylformamide dimethylacetal yields the pyrimido[4,5-c]isoquinolinones (5a-j). In this process, the intermediate of cyclization was isolated. The structure of the synthesized compounds was determined on the basis of nmr measurements, especially by 1 H, 1 H-, 1 H, 13 C COSY, and DEPT. These compounds showed antifungal in vitro activity particularly against dermatophytes.