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Solvent-free condensation of aromatic aldehydes and 2,3-dimethyl-1-phenyl-3-pyrazolin-5-one by p-toruenesulfonic acid

✍ Scribed by Hideko Koshima; Mitsuo Hamada

Publisher: Journal of Heterocyclic Chemistry
Year: 2002
Tongue: English
Weight: 19 KB
Volume: 39
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570390538

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✦ Synopsis

Abstract

Solvent‐free condensation easily occurred by mixing aromatic aldehydes and 2,3‐dimethyl‐1‐phenyl‐3‐pyrazoline‐5‐one (antipyrine) in the presence of p‐toluenesulfonic acid as a solid acid catalyst at room temperature to give the corresponding disubstituted products as sole products in high yields.

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