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Solvent-Free Condensation of Aromatic Aldehydes and 2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one by p-Toluenesulfonic Acid.

✍ Scribed by Hideko Koshima; Mitsuo Hamada


Publisher
John Wiley and Sons
Year
2003
Weight
89 KB
Volume
34
Category
Article
ISSN
0931-7597

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Solvent-free condensation of aromatic al
✍ Hideko Koshima; Mitsuo Hamada 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 19 KB 👁 1 views

## Abstract Solvent‐free condensation easily occurred by mixing aromatic aldehydes and 2,3‐dimethyl‐1‐phenyl‐3‐pyrazoline‐5‐one (antipyrine) in the presence of __p__‐toluenesulfonic acid as a solid acid catalyst at room temperature to give the corresponding disubstituted products as sole products i

Synthesis of 4-fluoro-2, 3-dimethyl-1-ph
✍ C.-Y. Shiue; A. P. Wolf 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 268 KB

## Abstract A facile procedure for preparing 4‐fluoroantipyrine is reported. Treatment of antipyrine with molecular fluorine gives 4‐fluoroantipyrine (3) and 4,4‐difluoro‐3‐hydroxy‐2,3‐dimethyl‐1‐phenylpyrazolidin‐5‐one (2). The product distribution depends on the ratio of antipyrine and molecular