Solvent dielectric attenuation of substituent effects. Dependence on boundary representation in prolate spheroidal cavity models

✍ Scribed by S. Ehrenson

• Book ID: 102879397
• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 622 KB
• Volume: 5
• Category: Article
• ISSN: 0192-8651
• DOI: 10.1002/jcc.540050108

✦ Synopsis

Extension of the inhomogeneous continuum solvent model to prolate spheroidal cavity systems in the context of Kirkwood-Watheimer substituent-reactivity theory is described. Reasonable effects attributable to electrical saturation and electrostriction, which are modeled by relatively simple spatial dielectric functions outside the solute-solvent boundary, may be demonstrated. It is also shown that choices of proper (i.e., nonaveraged) location of the interacting sites and magnitude of substituent dipole moments are comparably important to the quality of theoretical prediction.