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Solution structure of the SH3 domain of phospholipase C-γ

✍ Scribed by D. Kohda; H. Hatanaka; M. Odaka; V. Mandiyan; A. Ullrich; J. Schlessinger; F. Inagaki

Book ID: 119064427
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 821 KB
Volume: 72
Category: Article
ISSN: 0092-8674
DOI: 10.1016/0092-8674(93)90583-c

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## Abstract Phospholipase C‐γ1 (PLCγ1) plays a critical role in cell growth and proliferation by generating the second messengers, diacylglycerol and 1, 4, 5‐inositol triphosphate. To investigate the roles of Src homology domain 2 and domain 3 of PLCγ1 in PLCγ1‐mediated cell signaling, we character