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An SH3 domain is required for the mitogenic activity of microinjected phospholipase C-γ1

✍ Scribed by Pearl S. Huang; Lenora Davis; Hans Huber; Paula J. Goodhart; Ron E. Wegrzyn; Allen Oliff; David C. Heimbrook

Book ID
115929851
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
824 KB
Volume
358
Category
Article
ISSN
0014-5793

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## Abstract Phospholipase C‐γ1 (PLCγ1) plays a critical role in cell growth and proliferation by generating the second messengers, diacylglycerol and 1, 4, 5‐inositol triphosphate. To investigate the roles of Src homology domain 2 and domain 3 of PLCγ1 in PLCγ1‐mediated cell signaling, we character