Solution structure of the calicheamicin γ1I-DNA complex
✍ Scribed by R.Ajay Kumar; Norihiro Ikemoto; Dinshaw J Patel
- Book ID
- 115627684
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 869 KB
- Volume
- 265
- Category
- Article
- ISSN
- 0022-2836
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The chemical synthesis of two analogues of the calicheamicin oligosaccharide is described.
Calicheamicin yI1 is a natural product that has recently received much attention for its potent cytotoxic activity and its ability to bind and cleave duplex DNA in a sequence-specific manner. The solution structure of the calicheamicin oligosaccharide domain has been determined in complex with the D
Triggering and Bergman cyclization of calicheamicin gamma(1) (I) outside and inside the minor groove of the duplex 9mer-B-DNA sequence d(CACTCCTGG).d(CCAGGAGTG) were investigated by using density functional theory and molecular mechanics (DFT and MM) descriptions in which the ligand is completely de