Synthesis of analogues of the calicheamicin γ1I oligosaccharide as potential DNA ligands
✍ Scribed by Stéphane Moutel; Jacques Prandi
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 254 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The chemical synthesis of two analogues of the calicheamicin oligosaccharide is described.
📜 SIMILAR VOLUMES
The efficient preparation of a novel analogue of the BCD oligosaccharide domain of Calicheamicin y~x is described in which the thioester linkage found in the natural product is replaced by an ester group.
Calicheamicin yI1 is a natural product that has recently received much attention for its potent cytotoxic activity and its ability to bind and cleave duplex DNA in a sequence-specific manner. The solution structure of the calicheamicin oligosaccharide domain has been determined in complex with the D
Triggering and Bergman cyclization of calicheamicin gamma(1) (I) outside and inside the minor groove of the duplex 9mer-B-DNA sequence d(CACTCCTGG).d(CCAGGAGTG) were investigated by using density functional theory and molecular mechanics (DFT and MM) descriptions in which the ligand is completely de