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Solution-phase synthesis of an O-phosphoseryl-containing peptide using phenyl phosphorotriester protection

✍ Scribed by J.W. Perich; P.F. Alewood; R.B. Johns

Book ID: 104218345
Publisher: Elsevier Science
Year: 1986
Tongue: French
Weight: 207 KB
Volume: 27
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)84262-8

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✦ Synopsis

The solution-phase synthesis of TFA -Hz-Gtu-PSer-Leu 2 is reported using the protected phosphoroamino acid, N,-tert-butoxycarbonyZ-O-(diphenyZphosphosphoro)-L-ser~ne 4.

In our previous communicationl. we reported the synthesis of Glu-PSer-Leu 1 using a protected 0-(dibenzylphosphoro)serine derivative. This synthesis involved initial preparation of the protected tripeptide Boc-Glu[OBzll-Ser[PBz121-Leu-OBzl using

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