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Solid-phase synthesis of an O-phosphoseryl-containing peptide using phenyl phosphorothriester protection

โœ Scribed by J.W. Perich; R.M. Valerio; R.B. Johns

Book ID
104218346
Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
206 KB
Volume
27
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The solid-phase synthesis of TFA l X2-Glu-PSer-Leu 1 is reported via incopporation of the protected phosphoroamino acid N,-tert-butoxycarbonyI-O-(dipheny~photrphoro)-L-serine .&. The efficient synthesis of TFA l HZ-Glu-PSer-Leu L using Boo-Ser[PPh21-OH & demonstrates that N-protected 0-(disubstitutedphosphorohaerine derivatives are readily adapted to solid-phase peptide synthesis and indicates that the synthesis of longer and more complex 0-phosphoserine-containing peptides to be a practical proposition. w:~ A The authors acknowledge the financial support of the Australian Wool Board and ARGS. R.M.V. acknowledges a CPR Award. We also thank Dr. P.F. Alewood for useful background discussions.

๐Ÿ“œ SIMILAR VOLUMES

Solution-phase synthesis of an O-phospho
Solution-phase synthesis of an O-phosphoseryl-containing peptide using phenyl phosphorotriester protection
โœ J.W. Perich; P.F. Alewood; R.B. Johns ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 207 KB

The solution-phase synthesis of TFA -Hz-Gtu-PSer-Leu 2 is reported using the protected phosphoroamino acid, N,-tert-butoxycarbonyZ-O-(diphenyZphosphosphoro)-L-ser~ne 4. In our previous communicationl. we reported the synthesis of Glu-PSer-Leu 1 using a protected 0-(dibenzylphosphoro)serine derivati