Solution-phase parallel tetrahydrofuran synthesis with propargyl alcohols and benzylidene-(or alkylidene-)malonates

✍ Scribed by Marcello Cavicchioli; Xavier Marat; Nuno Monteiro; Benoı̂t Hartmann; Geneviève Balme

• Book ID: 104250737
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 191 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00313-1

✦ Synopsis

A large array of 3-methylene tetrahydrofurans has been synthesized from propargylic alcohols and activated olefins. The reaction is promoted by copper iodide that is removed at the end of the reaction by simple filtration, affording the desired heterocycles in high yield and purity.