Solution-Phase Parallel Synthesis of Substituted Benzimidazoles
โ Scribed by Raju, B.; Nguyen, Noel; Holland, George W.
- Book ID
- 126072515
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 96 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1520-4766
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๐ SIMILAR VOLUMES
A solid-phase synthesis of benzimidazoles, substituted on the aromatic ring by a variety of groups or atoms, is described. Intermediate 3, derived from the acylation of a resin-bound secondary amine with Fmoc-glycine, was elaborated via nucleophilic displacement with substituted o-halonitroarenes to
The value of ฮฑ,ฮฒ-unsaturated ketones (chalcones) as templates for the combinatorial assembly of N-substituted 2-pyrazolines has been explored. Based on a set of 80 chalcones, an array of 1500 N-carbamoyl, carbonyl and sulfonyl pyrazolines were produced demonstrating that a broad range of diversity c