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Solution-phase parallel oxazole synthesis with TosMIC

✍ Scribed by Bheemashankar A. Kulkarni; A. Ganesan

Book ID
104261833
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
117 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

A quaternary ammonium hydroxide ion exchange resin catalyzes the reaction of p'tolylsulfonylmethyl isocyanide (TosMIC) with aromatic aldehydes to give 5-aryloxazoles. The base and the ptolylsulfinic acid byproduct are removed by simple filtration, resulting in oxazoles in high yield and purity.

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